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August 6, 1898

UPON THE EXISTENCE OF A MINUTE MICRO-ORGANISM IN CASES OF CIRRHOSIS OF THE LIVER.

JAMA. 1898;XXXI(6):305. doi:10.1001/jama.1898.02450060043005
Abstract

While working with the so-called Pictou Cattle Disease, in 1894-5, Professor Adami of Montreal, obtained from the livers and abdominal lymph glands a characteristic micro-organism. The striking feature of this disease is an extensive cirrhosis of the liver, accompanied by swelling of the periportal and retroperitoneal lymph glands, with some ascites, and with follicular ulceration of the fourth stomach. The recognizable symptoms, the most marked of which is falling off of the milk, which becomes bitter when heated, occur shortly before death. Hence the cirrhosis must have been advancing for some time without producing any symptoms.

The microbes referred to are very difficult to stain, that is to say, they stain easily but lose their stain with extreme facility. They are also extremely minute, being barely recognizable with a fifteenth immersion lens.

The presence of these micro-organisms in the cirrhosis of the liver of Pictou Cattle Disease led Adami1

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