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—A recent Geneva thesis by J. Olivier reports the results of the investigation of the eliminating power of pregnant women by means of methylene blue or rosanilin. The elimination was found normal in many cases which presented the severest symptoms clinically. In other cases, the elimination was notably defective while the course of the pregnancy and puerperium was normal. In five cases of eclampsia, the elimination was defective in all but one. In this patient the elimination was perfectly regular, but the symptoms were far more severe in this case, and it terminated fatally. Olivier concludes that renal or hepatic insufficiency is not inevitably necessary to the production of autointoxication. The pathogenesis in certain cases evidently includes an overproduction of toxins. The elimination of such excessive amounts is impossible in spite of the integrity of the natural emunctories.
Study of the Autointoxications of Pregnancy.. JAMA. 1902;XXXVIII(25):1628. doi:10.1001/jama.1902.02480250022012