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Senility embraces that period of life during which one or more of the functions, as well as nutritional metamorphoses, when compared with the manifestations of the vital unit possessed by the individual, are recognized to be prematurely waning, and thus many are the instances of men and women, who, being endowed with vital energy sufficient to enroll them among the normal activities of advanced being, remain more or less disabled or invalided because of this premature failure on the part of some special organ or system to adequately discharge function. This retrograde process has an insidious origin, manifesting itself much earlier in life than we are prone to imagine, and is primarily operative, as a rule, in the vasomotor system. This great system has not, as yet, received the attentive study it should, and its direct relationship to functional activity, whether it be of brain or special sense or organ,
BEATES H. THE CONTINUOUS USE OF DIGITALIN IN THE VASOMOTOR AND CARDIAC LESIONS OF SENILITY.. JAMA. 1898;XXXI(14):761-763. doi:10.1001/jama.1898.92450140015001f