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From time immemorial certain phases or symptoms of disease which have been uncertain in their pathology or whose pathology has been unknown, have been classified under general terms, vague and uncertain; and these terms have varied with the ages. Time was when the humors of the body accounted for all manifestations of disease which could not be accounted for or classified by the scapel, inspection, or inductive reasoning from the most simple and elementary medical facts. Humors have passed, and we now classify such disturbance as manifestations of a diathesis, or of chronic rheumatism or gout, of the presence in the blood of nerve irritants, as uric acid, toxalbumins, auto-infections, etc., or as due to the cries of sensitive nerves for pabulum which an impoverished circulatory medium no longer furnishes them, and call them neuralgia.
The longer I study the matter, the more am I inclined to believe that a
LODOR CH. NEURALGIA AND NERVE CRIES.. JAMA. 1898;XXXI(19):1088–1090. doi:10.1001/jama.1898.92450190012002d