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The profession is coming to recognize more and more the interdependence in health and disease which exists between the various organs of the body, and that maladies which exert their primary and dominant influence upon one organ may simultaneously or consequently seriously derange another part far removed from the site of the early lesion. In no organs of the body is this interdependence of function better developed than in those which occupy the abdominal cavity, or lie in adjacent parts, and as a result of this we see secondary renal changes following diseases in the liver, the spleen and the intestinal canal in a considerable number of maladies. It is, however, particularly in those diseases which are called infectious that the kidneys are apt to suffer, for they are the organs by which the toxins or poisonous matters produced by the infecting micro-organism must be chiefly eliminated from the body,
THE RELATION OF MALARIA TO RENAL DISEASE.. JAMA. 1898;XXXI(20):1181. doi:10.1001/jama.1898.02450200049005