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July 29, 1899


JAMA. 1899;XXXIII(5):296-297. doi:10.1001/jama.1899.02450570054015

There is yet wanting unanimity of opinion as to the exact relation between smallpox and cow-pox, and the question has not been decided whether the two are expressions of the same disease modified by the soil in which they are implanted, or are really distinct diseases. However this may be, it is certain beyond peradventure that inoculation of human beings with cow-pox affords protection from and does not give rise to smallpox, and while vaccination is occasionally attended with noteworthy constitutional symptoms, it is rarely accompanied by any other than the local exanthem. Cases have however, been placed on record in which vaccination was followed by a generalized eruption, and only recently Tyson reported such a case to the Philadelphia Pediatric Society. A most striking instance of the same sort has also been reported by D'Espine and Jeand1. The patient was a girl 11 months old, who was inoculated

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