So long as the tuberculin test has many strong opponents as well as ardent advocates, future evidence from the experience of those who are using it is of value in deciding its position as a method of diagnosis. Those who oppose its use for this purpose, take the ground that it is dangerous, either by rendering more active already existing disease which is in a more or less quiescent state, or by infecting the general system, or in both of these ways; or, on the other hand, that it is unreliable by giving reactions in other diseases, notably syphilis, and by not reacting in certain cases of tuberculosis, cases demonstrated to be such by other methods of diagnosis.
Its chief value, and I believe it is valuable, though not infallible, is in the assistance it renders us in detecting early and doubtful cases impossible of detection by other diagnostic methods.
OTIS EO. VALUE OF THE TUBERCULIN TEST IN THE DIAGNOSIS OF TUBERCULOSIS.. JAMA. 1899;XXXIII(18):1074-1076. doi:10.1001/jama.1899.92450700018001f