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Although alcoholism is considered the most potent and the most common cause of cirrhosis of the liver, there occur a not inconsiderable number of cases in which no history of excessive ingestion of this substance can be obtained, and not rarely no other etiologic factor can be distinctly ascertained. Malaria is also stated to be a causative factor. It will scarcely be contended that there is anything specific or selective in the action of alcohol in the development of cirrhosis of the liver, but it must rather be concluded that the morbid process is brought about by the irritating action of this substance on the interstitial connective tissues of that organ. It may, however, easily be that the liver is more responsive to the stimulation of alcohol than to that of other irritants. At the same time, it should be borne in mind that the liver, by virtue of its
CIRRHOSIS OF THE LIVER IN EARLY LIFE.. JAMA. 1900;XXXIV(3):179-180. doi:10.1001/jama.1900.02460030053021