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January 27, 1900


JAMA. 1900;XXXIV(4):239-240. doi:10.1001/jama.1900.02460040049007

Some of the statements made recently in these columns (p. 179), with regard to the occurrence of interstitial changes in the liver, particularly in young persons, are susceptible of general application to analogous changes in other tissues and organs. The danger from all conditions of this nature depends on the establishment of a vicious circle, in which hyperplasia of the interstitial tissue either takes place primarily or occurs as a result of previous destruction of parenchymatous tissue, and this in turn causes further destruction of parenchymatous elements, this process continuing until it reaches a degree that is incompatible with the continuance of life. It is likely, further—in fact it is the rule—that that same process may involve many organs and tissues contemporaneously or successively, though, as observation has shown, in varying degree. This fact would seem to indicate that the different organs exhibit differences in respect to their response to

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