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January 27, 1900


JAMA. 1900;XXXIV(4):241-242. doi:10.1001/jama.1900.02460040051013

It is recognized as an established clinical fact that acute infectious disease occurring in an epileptic has a tendency to suppress the convulsive seizures, at least temporarily; though these may subsequently recur with their original or even increased frequency and severity. It has been thought that malarial infection especially exerted a favorable influence on epilepsy, but a series of fourteen observations made by De Montyel1, in the course of eleven years, would seem to demonstrate the contrary. In five cases of mild epilepsy, with slight attacks at long intervals, and with little mental impairment, the symptoms were aggravated in the sequence of attacks of intermittent fever, which themselves yielded readily enough to quinin. In three cases in which there had been no convulsive seizures for a number of years, the attacks returned under the influence of malarial infection. In the remaining six epileptic attacks occurred for the first time

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