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While perhaps typhoid fever is the more prevalent above and malarial fever below Mason and Dixon's line, the fact should not be lost sight of that cases of each may occur under circumstances amid which they would be least expected. With the information to be gained from examination of the blood as to the presence of plasmodia on the one hand, and of agglutination and sedimentation on the other, in conjunction with other more or less distinctive symptoms, there should be little room for error in the diagnosis of these two diseases. While such error is the more likely to occur from failure in observation, it must in fairness be admitted that the diagnosis may in some cases remain in doubt from a concurrence of unusual circumstances. Of all men the physician must ever be prepared for the unexpected, and he should constantly fortify himself against surprise. A forcible illustration
PERNICIOUS MALARIAL FEVER.. JAMA. 1900;XXXIV(4):243–244. doi:10.1001/jama.1900.02460040053018