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So conclusive is the evidence in support of the efficacy of vaccination and revaccination in the prevention of smallpox that there would be no occasion for extended discussion of this subject were not attempts persistently made to discredit the statistics or to attribute the results to other influences. It can not be succesfully denied that the prevalence of, as well as the mortality from, smallpox has diminished enormously since the general adoption of vaccination and revaccination. In addition, the severity of the disease in individual cases has diminished, and disastrous complications, so commonly observed in the past, are to-day rare and exceptional; and there is practically no evidence whatever that this improved condition of affairs can be ascribed in any notable degree to any other factor or combination of factors. There is absolutely no ground for the opposition that is manifested in some places to this most beneficent procedure.
PROPHYLACTIC VALUE OF VACCINATION AND REVACCINATION.. JAMA. 1900;XXXIV(7):432–433. doi:10.1001/jama.1900.02460070048005