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February 17, 1900

DEGENERATION AND REGENERATION OF NERVE ENDINGS IN VOLUNTARY MUSCLE.

JAMA. 1900;XXXIV(7):437. doi:10.1001/jama.1900.02460070053013
Abstract

Our knowledge concerning the changes in motor and sensory nerve endings is as yet in its infancy. Huber2 has made an experimental study of the degenerative and regenerative changes that occur in these structures after severance of the nerves. The nerve used was the posterior tibial nerve of the rabbit, and the endings studied were situated in the interossei muscles. At the same time the neuromuscular and neurotendinous spindles in the muscles were also examined. It is shown, by Huber's study, that the electric stimulation of the nerve is not followed by any response of the muscle when structural changes in the motor endings and the fibers of the medullated nerves have appeared following the experimental division of the nerve. This occurs about twenty-three to forty-six hours after crushing the nerve. The changes in the motor nerve endings, as shown by the intra vitam methylene blue method, are ushered

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