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March 17, 1900


JAMA. 1900;XXXIV(11):694. doi:10.1001/jama.1900.02460110054013

Enlargement of the thyroid gland may often be observed in the early stages of syphilis, and it appears not to be directly influenced by antisyphilitic treatment, gradually and slowly receding like enlargement of the lymphatic glands. Suppuration, diffuse interstitial inflammation, gummata and hemorrhage may occur in the thyroid gland as manifestations of hereditary syphilis. Cases are on record in which myxedema has appeared to be of syphilitic origin. Further, circumscribed nodular infiltration and gummata have been found in the thyroid gland in cases of syphilis. A case of unusual character in this connection has been reported by Wermann.1 A man, 24 years old, with a history of syphilis, for which he had at different times received treatment with mercurials and iodids, developed, six years after the primary infection, progressively increasing enlargement of the thyroid gland, while still taking potassium iodid. There were no nodules and no dense infiltration, and

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