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Article
April 7, 1900

METHEMOGLOBINEMIA FROM CERTAIN DRUGS.

JAMA. 1900;XXXIV(14):883. doi:10.1001/jama.1900.02460140055017
Abstract

There are a number of drugs—some oxidizing, some reducing agents and others of neither character—capable of converting the oxyhemoglobin of the blood into methemoglobin and thus exerting a distinctly injurious influence. This condition is indicated spectroscopically by a band in the red portion of the spectrum between the lines C and D. This becomes the deeper and the more pronounced the greater the amount of methemoglobin present, while it disappears on addition of alkalies or on strong dilution with water. Two other bands appear in the green portion of the spectrum between the lines D and E, and these are supposed to be of quantitative value. To determine the influence on the blood in this connection, of two of the more recently introduced antipyretics, acetanilid and phenacetin, Dennig2 undertook a series of spectrophotometric observations and found that these substances introduced into the stomach or the bowel of the dog

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