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April 14, 1900

THE PRODUCTION OF CARCINOMA BY EXPERIMENTAL DISSEMINATION OF EPITHELIAL CELLS.

JAMA. 1900;XXXIV(15):943. doi:10.1001/jama.1900.02460150049011
Abstract

H. Lambert Lack1 in a preliminary note, describes an experiment which he made in order to test his view that carcinoma is simply the result of the entrance of the normal epithelium of the body into the lymphatic spaces and its continued growth therein. Opening the abdominal cavity of two rabbits, the ovaries were cut open, the raw surfaces freely scraped, and the milky juice containing free epithelial cells thus obtained, was allowed to diffuse through the peritoneal cavity. In the animal which survived for about one year numerous peritoneal nodules were found extending into the liver, and similar growths on the pleura, the pericardium, in the lungs and in the mediastinum. The microscopic structure was that of a columnar-celled carcinoma. Unfortunately for the value of this experiment, which is tentatively claimed to have produced the disease, and has been so interpreted by others, the condition of the uterus

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