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May 12, 1900


JAMA. 1900;XXXIV(19):1201. doi:10.1001/jama.1900.02460190051016

This designation has been applied to a condition in which it is supposed that there exists asynchronous action of the ventricles of the heart, so that with each contraction of one ventricle, one or more contractions of the other take place. The evidence as to the actual occurrence of such a phenomenon is, however, not conclusive. For obvious reasons the demonstration can only be made by experimental means, but the observations that have thus far been recorded in this connection are not wholly free from criticism. For these reasons Frank and Voit1 undertook an investigation of the subject with the aid of specially devised apparatus. They employed a rubber manometer and made their observations on rabbits and dogs. Narcosis was induced by curare, the thorax opened in the middle line and a small, curved metallic catheter introduced through the left auricle and fastened into the left ventricle, while a

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