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May 12, 1900


JAMA. 1900;XXXIV(19):1202-1203. doi:10.1001/jama.1900.02460190052019

Although much has been written on the subject of uric acid, it can not be said that there is universal agreement as to its influence in the causation of disease, or as to the means of affording relief from its reputed manifestations. While perhaps our present nomenclature may prove to be incorrect and current explanations inadequate, it is safe to assume that certain derangements in metabolic activity are capable of bringing about morbid manifestations of a more or less definite and sometimes even alarming character. Of this we have evidence in the development of gout, of diabetes, and of the condition or process that correctly or incorrectly, it is customary to speak of as uric-acid intoxication. Care must, however, be taken not to generalize too freely on the basis of scant knowledge of a precise character. The individual factor should never be forgotten or ignored, and a growing experience teaches

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