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Medical News & Perspectives
January 12, 2011

Experts OK Antiplatelets and PPIs for Heart Patients With GI Bleeding Risks

JAMA. 2011;305(2):135-136. doi:10.1001/jama.2010.1907

After 2 years of confusion and anxiety from conflicting research results, physicians have new guidance in determining which patients with cardiovascular disease who take antiplatelet therapy will reap the most benefit from also taking a proton pump inhibitor (PPI) to reduce the risk of gastrointestinal (GI) bleeding.

In mid-November, the American College of Cardiology Foundation, the American College of Gastroenterology, and the American Heart Association released a consensus document that gives a green light to the concomitant use of antiplatelet drugs and PPIs in patients who are at high risk for upper GI bleeding (

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