To the Editor: In their randomized controlled trial, Dr Hajjar and colleagues1 studied transfusion requirements after cardiac surgery. The equipoise for conducting a randomized controlled trial of a liberal vs a more restrictive transfusion strategy in association with cardiac surgery was well described. However, we have significant concerns regarding the statistical design of this trial that greatly limit any conclusions that can be drawn.
McIlroy D, Argenziano M. Blood Transfusion and Cardiac Surgery. JAMA. 2011;305(4):357-359. doi:10.1001/jama.2011.13