High doses of vitamin D3 added to antibiotic treatment can help clear the bacteria that cause tuberculosis (TB) more quickly in a subset of patients with a particular variant of vitamin D receptor, according to a new study from investigators across the United Kingdom (Martineau AR et al. Lancet. 2011 Jan 15;377:242-50).
In this randomized controlled trial, 126 patients with drug-sensitive TB had inadequate levels of vitamin D, a common problem with this disease. In addition to receiving antibiotic therapy, the 62 patients in the intervention group received 4 doses of 2.5 mg of vitamin D3 and the 64 patients in the control group were given a placebo.
Friedrich MJ. Vitamin D and TB Recovery. JAMA. 2011;305(7):663. doi:10.1001/jama.2011.137