New findings indicate that the most commonly mutated genes associated with pancreatic neuroendocrine tumors (PanNETs) encode proteins involved in chromatin remodeling, a process that can regulate gene expression through changes in the complex of DNA and protein that packages DNA into chromosomes (Jiao Y et al. Science. doi:10.1126/science.1200609 [published online ahead of print January 20, 2011]).
Hampton T. Pancreatic Tumor Genes. JAMA. 2011;305(9):876. doi:10.1001/jama.2011.217