Use of the pesticides rotenone and paraquat is associated with an increased risk of developing Parkinson disease, report researchers from the National Institute of Environmental Sciences and the Parkinson's Institute and Clinical Center, a nonprofit research and clinical center in Sunnyvale, Calif.
In a nested case-control study of participants in the Agricultural Health Study, the researchers compared 110 persons with Parkinson disease with 358 controls and found that individuals who used paraquat or rotenone had 2.5 times higher odds of developing the disease (Tanner CM et al. Environ Health Perspect. doi: 10.1289/ehp.1002839 [published online ahead of print January 26, 2011]).
Kuehn BM. Parkinson Disease and Pesticides. JAMA. 2011;305(12):1188. doi:10.1001/jama.2011.318