Author Affiliations: Department of Nutritional Sciences, Obesity Group, Rutgers University, New Brunswick, New Jersey (Dr Shapses); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Dr Manson).
Vitamin D has received widespread attention for its potential role in preventing cardiovascular disease and type 2 diabetes mellitus. Several epidemiological studies have suggested that individuals with low blood levels of vitamin D have increased risks of heart disease, stroke, hypertension, and diabetes. Yet the evidence that vitamin D prevents cardiometabolic outcomes played an inconsequential role in determining the population needs for vitamin D in the 2011 report from the Institute of Medicine (IOM).1 How is it possible that such a large body of evidence had so little influence on the recommended intakes for vitamin D? This commentary, authored by 2 members of the IOM Committee, provides a critical appraisal of the relevant evidence, explains why the research was found to be insufficient by the IOM, and identifies future research needs on this topic.
Shapses SA, Manson JE. Vitamin D and Prevention of Cardiovascular Disease and DiabetesWhy the Evidence Falls Short. JAMA. 2011;305(24):2565-2566. doi:10.1001/jama.2011.881