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Article
January 11, 1965

PATTERNS OF ABNORMALITY IN METASTATIC CARCINOMA OF THE LIVER

JAMA. 1965;191(2):130. doi:10.1001/jama.1965.03080020058018
Abstract

Determination of the presence and extent of metastatic carcinoma of the liver is often an important adjunct to management of patients with malignant disease. Tan and associates1 have recently described a combination of laboratory tests which may be clinically useful in the estimation of hepatic neoplastic involvement. These investigators suggest that the determination of sulfobromophthalein (BSP) excretion, the serum values of bilirubin, alkaline phosphatase, thymol turbidity and cephalin flocculation tests, glutamic oxalacetic transaminase (SGOT), and one of the glycolytic enzymes may provide a pattern of abnormality which is characteristic of metastatic carcinoma of the liver. These recommendations are based upon the study of hepatic dysfunction and serum enzyme abnormalities in 284 patients proved to have hepatic metastatic malignancy. The test most frequently abnormal was the BSP excretion; approximately 90% of the patients studied with this procedure showed impaired excretion of the dye. The incidence of abnormal alkaline phosphatase levels

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