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January 18, 1965

Lipid Mobilizer Hormone in Cobalt Chloride Hyperlipemia

Author Affiliations

From the departments of internal medicine (Simpson Memorial Institute) and pathology, University of Michigan.

JAMA. 1965;191(3):235-237. doi:10.1001/jama.1965.03080030079010

A lipid-mobilizing hormone (LM) was discovered in the plasma of man and other species by Seifter and Baeder1 in 1954. These investigators later isolated LM from the posterior pituitary gland of hogs2 and demonstrated that the plasma content of LM is greatly increased by the administration of cortisone and by subjecting animals to various stresses.1,3 LM exerts two major effects: (1) it mobilizes fatty acids from the omental and mesenteric depots, and (2) it inhibits the delactescent action of heparin-clearing factor in vitro. Extensive clinical and laboratory studies have shown LM to be involved in the elevation of blood lipids which occurs consequent to surgical stress,4,6 pregnancy,5 and nephrosis,1 as well as in hereditary hyperlipemias.4 In addition, the hyperlipemias induced by protamine7 and by diisopropyl fluorophosphate7 appear to be mediated by the LM mechanism.

This investigation was done to determine whether

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