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To the Editor:—
Arthus' phenomenon, the local necrosis of tissue after injection of antigen in a sensitized animal, has been used to slough implanted tumors in experimental animals. Because I have had cases of extensive hemangiomas that have sloughed and regressed after partial excision, it occurred to me that the partial excision might have released an antigen that precipitated the process, which itself was perhaps an expression of the auto-immune disease process, destruction of seemingly normal tissue by the immune reaction. I have not had a non-resectable hemangioma on which I could try my thesis. I have had, however, two cases with extensive lymphangioma-hemangioma in which total excision was out of the question. In the first patient an extensive lymphangioma with minimal areas of capillary hemangioma involved the right arm only. In the second patient an extensive lymphangioma with minimal capillary hemangioma involved many areas of the body.On the
Johnson HA. Lymphangioma and Arthus' Phenomenon. JAMA. 1965;191(7):602-603. doi:10.1001/jama.1965.03080070086025