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March 8, 1965

Transfusion Complications

Author Affiliations

Chairman, Committee on Standards American Association of Blood Banks Brookline, Mass

JAMA. 1965;191(10):866. doi:10.1001/jama.1965.03080100084034

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To the Editor:—  In The Journal of Nov 23, 1964 (190:773), appears an excellent editorial on the prevention of transfusion complications. There is, however, one suggestion to which exception can be taken, namely, that a major crossmatch in an antiglobulin system should be determined only in patients who have been pregnant or who have received previous transfusions. This is certainly less than an acceptable standard in today's blood-bank methodology. As a minimum standard, a major crossmatch in an antiglobulin system or its equivalent should be part of every compatibility test. I doubt that there are many transfusionists who would be willing to omit the indirect antiglobulin (Coombs') test as part of the routine examination of recipient's serum in every crossmatch.One other point should be stressed and that is the saving of a small sample of the patient's blood for at least seven days after each transfusion, as there

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