Hyperbaric oxygenation was used in the treatment of purpura gangrenosa (fulminans). Hyperoxic therapy was employed in an apparently successful effort to reverse and prevent ischemic tissue damage. The prompt improvement of involved areas during treatment and the subsequent complete resolution of the peripheral lesions with loss of tissue is unusual in this severe and commonly fatal illness. Further trial of hyperoxia in the prompt treatment of ischemia due to acute arterial occlusive disease is warranted.
Waddell WB, Saltzman HA, Fuson RL, Harris J. Purpura Gangrenosa Treated With Hyperbaric Oxygenation. JAMA. 1965;191(12):971-974. doi:10.1001/jama.1965.03080120005001