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April 5, 1965

Primary Generalized OsteoarthritisCase Report With Knee-Joint Fluid Analysis

Author Affiliations

From the Department of Medicine, University of California at Los Angeles. Dr. Swezey is now with the Department of Physical Medicine and Rehabilitation at UCLA.

JAMA. 1965;192(1):61-62. doi:10.1001/jama.1965.03080140067023

THE FIRST reported recognition of the existence of a polyarticular form of osteoarthritis was in 1805 by Haygarth.1 Cecil and Archer, in 1926,2 associated this disorder with the characteristic nodules of the distal and interphalangeal joints described by Heberden3 in 1802. A reaffirmation and description of this entity by Kellgren and Moore,4 in their analysis of 120 cases, has greatly stimulated interest and recognition of this disorder. Stecher,5 in his monumental study of the genetics of Heberden's nodes, has questioned the relationship of a generalized arthritis to Heberden's nodes. Traut, in writing about degenerative arthritis, speaks of "arthritis sicca," and states that "the joint swelling... in a joint affected by degenerative joint disease is classically bony or capsular rather than due to an increased quantity of synovial fluid."6

Kellgren's Disease  Primary generalized osteoarthritis (Kellgren's disease) is a disorder of middle-aged women predominantly, the ratio

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