Thirty-four pregnant patients with viral hepatitis form the basis of this prospective study. Of the 30 patients with adequate follow-up, 28 improved rapidly, 1 developed postnecrotic cirrhosis, and 1 died of massive hepatic necrosis. Fetal survival includes 22 full-term infants. There were eight premature labors (three resulting in twins, one induced), with six labors resulting in nine living infants. Two premature infants died. Two other pregnancies ended with spontaneous abortions. Neonatal hepatitis was not discovered. A favorable outcome may usually be anticipated for the mother with hepatitis. Fetal wastage attributable to hepatitis was no greater than the incidence observed in pregnant patients without this disease.
Adams RH, Combes B. Viral Hepatitis During Pregnancy. JAMA. 1965;192(3):195–198. doi:10.1001/jama.1965.03080160015003