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May 3, 1965

Hodgkin's Disease Diagnosed After Salmonella Infection

Author Affiliations

Veterans Administration Hospital San Francisco

JAMA. 1965;192(5):422. doi:10.1001/jama.1965.03080180080031

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To the Editor:—  I read with interest the report of Heineman and associates on "Hodgkin's Disease and Salmonella typhimurium Infection" (JAMA188:632-634 [May 18] 1964). The importance of the association between infection with this strain of Salmonella and Hodgkin's disease was emphasized in a patient seen in 1960 at this center.A 40-year-old Chinese male had a three-month illness characterized by chills, fever, and weight loss, without other significant symptoms or findings. S typhimurium was grown from blood, bone marrow, and urine cultures and he was treated with chloramphenicol. Since extensive diagnostic studies were unrevealing, it was assumed that the Salmonella sepsis accounted for the entire clinical picture. When he died three months after the onset of his illness, Hodgkin's disease confined to the retroperitoneal area was found. This had not been suspected clinically. At the time of this patient's hospitalization, the relationship between infection with this strain of

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