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July 12, 1965

Shrinking Specificity of Transaminase SGOT

Author Affiliations

Mobile, Ala

JAMA. 1965;193(2):169. doi:10.1001/jama.1965.03090020083032

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To the Editor:—  The editorial entitled "The Shrinking Specificity of the Transaminase Determination" (JAMA191:179 [March 29] 1965) is wrongly named. A better title would have been "Further Evidence Substantiating Congestive Hepatomegaly" as an etiology of elevated serum glutamic pyruvic transaminase (SGOT) level. These determinations are of value in myocardial infarction and diseases of the liver. Less informed persons might draw erroneous conclusions from the title used.I, as well as, I am sure, many others, have diagnosed subclinical congestive heart failure on the basis of a SGOT level of significant degree.As is true with many other laboratory procedures in clinical medicine, a test for one organ system becomes more and more specific as more diseases that cause pathophysiology of this particular organ system are studied and fewer exceptions are found.

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