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July 12, 1965

Histophysiology of Synapses and Neurosecretion

Author Affiliations

New Orleans

JAMA. 1965;193(2):173. doi:10.1001/jama.1965.03090020087045

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Events and structures fundamental to nervous-system function emerge from their previously invisible and unknown state through progress in electron microscopy. It is highly appropriate that this excellent compendium, and also assessment, of our knowledge should be set forth by de Robertis, who, with his colleagues, has pioneered many of these advances in electron microscopy of the central nervous system.

The book, which is written in a refreshingly straightforward style, is divided into major sections, the first of which deals with junctional transmission in the motor endplate and in various types of synapses. Fascinating glimpses into the ultrastructure of the transmission process emphasize the relationship of the microvesicles to the acetylcholine choline-acetylase system. Apparently other less-evident transmitter substances, such as norepinephrine, serotonin, and γ-amino butyric acid, as well as some of the enzymes associated with these, are generally related to the mitochondria.

The second section of the book is concerned with

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