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Proper management of carcinoma-in-situ of the uterine cervix, like that of any malignant neoplasm, is based upon a careful clinical evaluation of each patient, coupled with a thorough histological evaluation of the offending lesion, and requires close cooperation among clinician, pathologist, and patient. The clinician must assess individual physiological status and clinical extent of disease. He must also provide a competent pathologist with adequate tissue for study. In turn, the clinician must obtain the cooperation of the patient in order to carry out appropriate therapy and to be assured of the opportunity for extended observation of therapeutic results. There is no single treatment for all malignant lesions that can occur in a given site. The extent and character of a lesion, areas of involvement, physical condition of the individual patient, and experience, abilities, and even prejudices on the part of the physician all enter into the formulation of a therapeutic
Krieger JS, McCormack LJ. Conservative Management by Conization. JAMA. 1965;193(3):218. doi:10.1001/jama.1965.03090030040009