The precise part played by the kidney and its renin-angiotensin system in the production and maintenance of renovascular hypertension has been a subject of considerable debate possibly since 1898, when two Swedish scientists, Tigerstedt and Bergman,1 demonstrated that a saline extract of the rabbit's kidney was capable of producing elevated blood pressure in animals. They named this material renin. The precise part that alterations in renal-artery blood flow play in the production and maintenance of renovascular hypertension has also been a subject of considerable debate, although not for quite as long a time.
In an effort to elucidate the hemodynamic alterations within the renal artery necessary for the production of hypertension of renovascular origin, various operative techniques have been devised. In the operative procedure which serves as the basis for this report, the renal artery of one kidney was anastomosed to the femoral artery in the opposite leg by
Baron HC. Technique for Production of Renovascular Hypertension. JAMA. 1965;193(8):663-666. doi:10.1001/jama.1965.03090080025007