August 23, 1965

Doubling of Dosage of Penicillin In Treating Gonorrhea Recommended

JAMA. 1965;193(8):23-26. doi:10.1001/jama.1965.03090080063037

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Public health authorities this week recommended that physicians double the dosage of penicillin used in treatment of gonorrhea.

The recommendation is based on findings which indicate a continued increase in number of strains of Neisseria Gonorrhoeae with lessened susceptibility to penicillin.

The Venereal Disease Branch, Communicable Disease Center, US Public Health Service, Atlanta, issued an addendum to PHS Publication 859, Notes on Modern Management of VD. It recommends that the dosage of aqueous, procaine penicillin for men be increased from 1.2 million units to 2.4 million units. For women, it recommends increasing the dosage from 2.4 to 4.8 million units.

It was understood that the US Army Medical Corps is preparing similar recommendations for the treatment of soldiers.

CDC officials estimate an incidence of 1 million cases of gonorrhea in the United States each year.

William J. Brown, MD, Chief, Venereal Disease Branch, CDC, said the suggested increases in penicillin

First Page Preview View Large
First page PDF preview
First page PDF preview