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August 23, 1965

Precipitate from Cold-thawed Plasma Potent in Therapy for Hemophiliacs

JAMA. 1965;193(8):27-30. doi:10.1001/jama.1965.03090080067038

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Use of a precipitate from coldthawed plasma—until recently thought to be valueless—may solve several major problems inherent in conventional therapy for hemophiliacs.

Judith G. Pool, PhD, Stanford University Medical Center, is the investigator who first found—almost by accident—that the threadlike substance precipitated during standard cold-thawing of plasma contains concentrated antihemophilic globulin (AHG).

Recently, Dr. Pool reported a simple technique for extracting this protein fraction. Since then, clinicians at Stanford Medical Center have used the precipitate in solution to infuse 14 patients more than 60 times. There were no apparent side effects.

Dr. Pool, a physiologist, described to The Journal these advantages of the concentrate:

  • In vivo assay indicates the crycoprecipitate is 30 times as potent in AHG activity per given weight of protein as fresh frozen plasma, the conventional therapy, and 20 times that of normal fresh plasma.

  • Since the precipitate can be dissolved in small amounts of

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