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September 20, 1965

Peripheral Phenol Injections Reduce Spasticity

JAMA. 1965;193(12):31-32. doi:10.1001/jama.1965.03090120093044

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To relieve spasticity, and to overcome a major hindrance to rehabilitation for some patients with strokes, cerebral palsy, and multiple sclerosis, three physicians in California are trying a new therapeutic approach—peripheral nerve blocks by phenol injection.

"Unlike most central nervous system approaches, 3% phenol in solution when injected peripherally does not cause permanent muscle impairment as it reduces or temporarily eliminates spasticity," an anesthesiologist at Stanford University Medical Center told The Journal.

Daniel Feldman, MD, associate professor of medicine in rehabilitation, Jordan Katz, MD, assistant professor of anesthesia, and Leslie Knott, MD, assistant professor of medicine in rehabilitation, described recent preliminary clinical trials. One study involved 22 patients. Cause of spasticity included cerebrovascular accidents, spinal cord trauma, multiple sclerosis, cerebral palsy, brain trauma, brain tumor, and combined systems disease.

56 Nerves Blocked  Using 3% phenol in saline solution or water in volumes from 2 cc to 8 cc depending upon

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