Administration of a constant dosage of salicylate during the tapering of corticosteroid dosage resulted in a significant increase in the blood salicylate concentration in four patients, in one of whom, a young boy, severe salicylate intoxication developed. The simultaneous administration of corticosteroids and salicylate resulted in a blood salicylate concentration that was lower than expected. The renal clearance of salicylate was increased after corticosteroid administration in three of five subjects studied. The ability of corticosteroids to increase glomerular filtration rate and diminish tubular reabsorption of water might partially explain their ability to increase the clearance of salicylate.
Klinenberg JR, Miller F. Effect of Corticosteroids on Blood Salicylate Concentration. JAMA. 1965;194(6):601–604. doi:10.1001/jama.1965.03090190023006