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November 8, 1965

Effect of Corticosteroids on Blood Salicylate Concentration

Author Affiliations

From the Arthritis and Rheumatism Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Md. Dr. Klinenberg is now at Johns Hopkins Hospital, Baltimore. Dr. Miller is now at New York University School of Medicine.

JAMA. 1965;194(6):601-604. doi:10.1001/jama.1965.03090190023006

Administration of a constant dosage of salicylate during the tapering of corticosteroid dosage resulted in a significant increase in the blood salicylate concentration in four patients, in one of whom, a young boy, severe salicylate intoxication developed. The simultaneous administration of corticosteroids and salicylate resulted in a blood salicylate concentration that was lower than expected. The renal clearance of salicylate was increased after corticosteroid administration in three of five subjects studied. The ability of corticosteroids to increase glomerular filtration rate and diminish tubular reabsorption of water might partially explain their ability to increase the clearance of salicylate.