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November 15, 1965

Rabbits Used to Produce Antisera Specific Against Some Human Cancers

JAMA. 1965;194(7):31-33. doi:10.1001/jama.1965.03090200153051

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A microbiologist from Baylor University has reported producing antisera specifically reactive against certain human cancers —work which the investigator says has been needed for development of a cancer vaccine.

The antisera contain antibodies produced in rabbits by immunization with purified DNA-nucleus complexes extracted from human cancer tissue at autopsy. After DNA-protein was tagged with fluorescein dye, the rabbit antiserum was used to stain sections of normal, cancerous, and other diseased human tissues.

"Tests with these purified, DNAbound protein (DNA-p) antibodies showed a remarkable selectivity for cancers," Sol Haberman, PhD, director of microbiology, told the American Society of Clinical Pathologists in Chicago.

When used to stain the same type of cancer from which the cancer cell fragments were taken, a marked immunofluorescence was seen in the nuclei of the cancer cells when viewed under the ultraviolet microscope. Normal tissue did not show positive reactions, he said.

The cancer tissue when treated

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