The Astrup technique was used in the management of the acid-base abnormalities in four cases of pulmonary disease and in 20 cases of cor pulmonale in which arterial carbon dioxide pressure was increased, indicating severe respiratory acidosis. A complete knowledge of the acid-base alterations in pulmonary insufficiency is mandatory for the overall management of patients with pulmonary disease. The Astrup technique of determining acid-base alterations is dependable, rapid, and accurate.
Dines DE, Olsen AM. The Value of Complete Knowledge of Acid-Base Derangement in Pulmonary Insufficiency. JAMA. 1965;194(10):1049–1052. doi:10.1001/jama.1965.03090230017004