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Article
December 13, 1965

THE CARCINOID SPECTRUM

JAMA. 1965;194(11):1241. doi:10.1001/jama.1965.03090240075024
Abstract

A decade has passed since the first description of metastasizing ileal carcinoid tumors which elaborate large amounts of serotonin. Since that time a "carcinoid syndrome" related to tumors arising in sites outside the small intestine has been substantiated. Melmon, Sjoerdsma, and Mason1 have recently reported that bronchial carcinoids may produce an interesting and distinctive variant of this syndrome. Recognition of these distinctive features may have diagnostic and therapeutic significance. Previous studies have alluded to certain striking variants of bronchial carcinoid tumors, including excess serotonin production in the absence of an associated clinical syndrome, secretion of 5-hydroxytryptophan as well as serotonin, predominance of left-sided cardiac lesions, and frequent metastases to bone. Melmon and associates identified these characteristics in their patients, but in addition they cite the possibility that flushing attacks in patients with a bronchial carcinoid syndrome may be unique. These attacks are more prolonged and more severe than in the

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