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Article
December 13, 1965

New Device Electronically Measures Man's Respiratory Reaction to Drugs

JAMA. 1965;194(11):37-38. doi:10.1001/jama.1965.03090240111054

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Abstract

An instrument which electronically measures a patient's respiratory reaction to drugs has been built and used clinically by two Harvard physicians.

The stereo set-sized device is the first capable of assessing both total respiratory resistance and nasal air flow, according to Leo J. Cass, MD, and Willem S. Frederik, MD, PhD.

The Cambridge, Mass, clinicianengineers received the 1965 Thomas G. Hull Award at the 19th American Medical Association Clinical Convention in Philadelphia for their exhibit.

Utilizing "a combination of known principles and a few new twists," Dr. Frederik built the instrument in the basement of his home.

Both standard and experimental agents have been used to plot their impact on patients with bronchial and allergic asthma, rhinitis, upper respiratory tract infections and other conditions. To date, the physicians explain, efforts have concentrated on improving the measuring device, not drug testing.

Potentially, Dr. Frederik notes, the device may be used in

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