December 13, 1965

Hemolytic Crisis in Rh-Positive Women

JAMA. 1965;194(11):49-50. doi:10.1001/jama.1965.03090240121057

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The sensitized Rh-negative woman does not present the only hemolytic crisis in obstetrics, a Philadelphia hematologist reminded colleagues at the American Medical Association Clinical Convention.

Within recent months, prenatal blood typing and serum screening have uncovered several potential problems among Rh-positive cases, said Lyndall Molthan, MD, director of the blood bank and transfusion service, Temple University Medical Center.

Among them:

  • A group-O woman who had antibodies which took one year to identify and who has only two compatible donors in the world.

  • Another group-O who had experienced nine pregnancies ending in stillbirths or neonatal deaths. Her husband is the only known adult with a rare, antigenic blood type ( Good-positive).

  • Yet another woman who had developed anti-Yta antibodies, prob ably from a 1949 transfusion. She is the tenth such patient known, and there are no known donors.

"Every prenatal patient must be considered as a future blood recipient;

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