December 20, 1965

Failure of Penicillin to Alter Acute Rheumatic Valvulitis

Author Affiliations

From the José Joaquin Aguirre Hospital (Drs. Vaisman and Correa), the Manuel Arriarán Hospital (Dr. Guasch), and the University of Chile and National Health Service of Chile, Santiago (Drs. Vaisman, Correa, Guasch, Vignau, and Schuster); and the Cleveland Metropolitan General Hospital and Western Reserve University School of Medicine, Cleveland (Drs. Mortimer and Rammelkamp). At the time these studies were conducted, Drs. Correa, Guasch, Schuster, and Vignau were research fellows and Dr. Vaisman was an associate in medicine of Western Reserve University (at the University of Chile). Dr. Guasch is now at the Roberto del Rio Hospital. Dr. Mortimer is a Markle scholar in academic medicine.

JAMA. 1965;194(12):1284-1286. doi:10.1001/jama.1965.03090250018003

A controlled study of the effects of penicillin on 165 patients with acute rheumatic fever has failed to demonstrate any alteration, attributable to the antibiotic, in valvular sequelae. The results suggest that the Streptococcus in the bacterial form does not play a continuing role in an acute episode of rheumatic fever once rheumatic symptoms have appeared.