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January 31, 1966

Blood-Volume Studies in Cardiac-Surgery Patients

Author Affiliations

From the departments of medicine (Drs. McClenahan and Yamauchi) and surgery (Dr. Roe), University of California Hospitals, San Francisco. Dr. McClenahan is now at the Palo Alto Medical Research Foundation and the Stanford University Health Service, Calif. Maj Yamauchi is now at the Tachikawa Hospital, Japan.

JAMA. 1966;195(5):356-361. doi:10.1001/jama.1966.03100050064020

Eleven adult patients who underwent cardiac surgery with extracorporeal circulation were studied with serial blood-volume determinations by radioactive-tag methods. Deficits were demonstrated postoperatively in ten, despite precise measurement and replacement of lost blood. As the usual clinical observations may not accurately reflect hypovolemia, direct measurement, when properly done, is a more reliable method for the estimation of blood volume. Of the two methods employed for measurement of blood volume, the use of radioactive chromium to tag red blood cells appears to be the more reliable when a single sampling technique is used.