[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
March 14, 1966

Histamine Sensitivity Of Bronchus Tested

JAMA. 1966;195(11):25. doi:10.1001/jama.1966.03100110017006

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Propranolol also was used in testing the bronchular sensitivity of normal and asthmatic or allergic patients to methacholine and histamine by Gerald Zaid, MD.

In normal humans, beta adrenergic blockade did not increase this sensitivity. A variable response was seen in patients with allergic rhinitis.

Marked sensitivity increases to methacholine were observed in asthmatics. But, because of the lack of response in normal subjects—despite considerable blockade—the role of partial beta blockage in asthmatic etiology was questioned.

Nevertheless, because of the marked parasympathetic response, propranolol should not be administered to asthmatics with angina or cardiac arrhythmias, concluded Dr. Zaid. He conducted his studies with Gildon N. Beall, MD, also of Los Angeles.

First Page Preview View Large
First page PDF preview
First page PDF preview