March 14, 1966

Cavernous Sinus Thrombosis Mimicked by CNS Lymphoma

Author Affiliations

From the departments of internal medicine (Dr. Crocker) and pathology (Dr. Lang), Madison (Wis) General Hospital.

JAMA. 1966;195(11):968-969. doi:10.1001/jama.1966.03100110136047

GENERALIZED LYMPHOMA is a disease which presents in many ways, including central nervous system (CNS) involvement. The present case displays not only an unusual neurological manifestation of lymphoma, cranial nerve involvement, but also shows that the disease process lymphoma can be difficult to diagnose. The reviews of the subject of CNS lymphoma mention the difficulty of diagnosis, and the rarity of lymphoma presenting with neurological symptoms.1 Whisnant presented a case of a 45-year-old man with a left 6th nerve palsy and other cranial nerve involvement due to a reticulum cell sarcoma in the left cerebellopontine angle and middle fossa.2 Sparling reported 118 cases of malignant lymphoma, 13 of which had brain involvement.3 Abbott described a syndrome caused by lymphomatous tumors arising in the eustacian tube, and involving all the cranial nerves in the middle fossa.4 Hutchinson studied 229 patients with lymphoma over a 20-year period, and

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