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March 28, 1966

Methohexital Anesthesia In Office Practice

JAMA. 1966;195(13):1157-1158. doi:10.1001/jama.1966.03100130131046

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To the Editor:—  Methohexital has proven extremely helpful in the office treatment of selective emotional disorders, thus making hospitalization unnecessary in many instances. Methohexital is a rapid and shortacting anesthetic, giving prompt recovery and having minimal, if any, aftereffects. It has greatly facilitated electroconvulsive therapy and can be used as an office procedure. It is superior to thiopental sodium, which is slower acting, gives a slower rate of recovery, and is associated with a greater incidence of side effects.

Procedure:—  patients are instructed to abstain from food and liquid on the morning treatment is to be given.Atropine, 1/75 grains, is administered subcutaneously approximately one hour prior to treatment. A 1% solution of methohexital is prepared by dissolving 500 mg in 50 cc of distilled water. The solution is administered intravenously by the drip method; occasionally a syringe is used. The amount required for satisfactory induction varies between 6 and

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